I’m constantly switching between Gnome and KDE (Bluefin, Aurora, Bazzite, Kinoite, Silverblue, whatever) and I never had any issues.
The only thing that gets messed up a bit is theming, where I have to change the GTK theme, and sometimes the window buttons when I go from KDE to Gnome, which is also reverted in just one click in Gnome tweaks.
Thanks for the summary!